CONSIDERATIONS TO KNOW ABOUT PKRRATING

The activated enzyme then phosphorylates its major substrate, the translational initiation element eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to your conserved family members of 4 protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in reaction to different stimuli12, triggering the built-i